A critical role for the NFkB pathway in multiple myeloma
نویسندگان
چکیده
منابع مشابه
A critical role for the NFkB pathway in multiple myeloma
NFkB transcription factors play a key role in the survival and proliferation of many kinds of B-cell tumors, including multiple myeloma (MM). It was shown that NFkB activation in MM tumors results mainly from extrinsic signaling by APRIL and BAFF ligands that stimulate receptors on normal plasma cells as well as on pre-malignant monoclonal gammopathy of undetermined significance (MGUS) and MM t...
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NFkB activity is critical for survival and proliferation of normal lymphoid cells and many kinds of B-cell tumors, including multiple myeloma (MM). NFkB activating mutations, which are apparent progression events, enable MM tumors to become less dependent on bone marrow signals that activate NFkB. Mutations that activate NFkB-inducing kinase (NIK) protein are the most prevalent among the many k...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2010
ISSN: 1949-2553
DOI: 10.18632/oncotarget.109